Leprosy consequences are huge regarding the psychological, social and economical aspects, although the rate of related lethality is low. The most important of them is the neuritis, which occurs associated with the leprosy reaction symptoms, triggered by delayed hyper sensibility, which determines and explains the therapeutic option based on immune suppressors combined with continuous antimicrobial chemotherapy. Mechanisms probably involved are explored at the same time as research perspectives worldwide are considered. In this context, it is pointed that the main challenge for the knowledge and intervention on Physical Disabilities in Leprosy is to overcome the semantic disagreements as well to understand the differences and traps protocols may provide. As it is widely known, leprosy is an infect-contagious disease related to Mycobacterium leprae, whose spectrum of manifestations depends on the immune response from the infected people.