Drug safety relates to the potential for adverse effects associated with the administration of medicine . Efforts to determine the safely profile of medicine begin early in their development, with in vitro and in vivo toxicity testing, and continue through clinical trials leading up to drug approval and following approval in specific post-marketing studies or general pharmacovigilance efforts. Information received from patients and healthcare providers via pharmacovigilance agreements (PVAs), also as other sources like the medical literature, plays a critical role in providing the info necessary for pharmacovigilance to require place. In fact, so as to plug or to check a pharmaceutical product in most countries, adverse event data received by the license holder (usually a pharmaceutical company) must be submitted to the local drug regulatory agency . DThe impact factor of Drug Safety journal may be a measure reflecting the typical number of citations to recent articles published within the journal. it's frequently used as a proxy for the relative importance of a journal within its field, with journals with higher impact factors deemed to be more important than those with lower ones.