Hoffman's syndrome is a specific, rare form of hypothyroid myopathy, which causes proximal weakness and pseudohypertrophy of muscles. It was first described in 1897 in an adult who developed muscle stiffness and difficulty in relaxation of muscles after thyroidectomy. Similar presentation in children with cretinism is referred as Kocher-Debré-Sémélaigne syndrome.[2] We discuss a case of hypothyroid male with this unusual and rare presentation.
A 45-year-old male presented with complaints of weakness in lower limbs and easy fatigability for last 8 months. He had difficulty in getting up from squatting position and climbing stairs. He also complained of frequent muscular cramps and stiffness and pain in muscles. There was no history of bladder or bowel involvement. There was no history of hypertension, diabetes, or any other chronic illness. There was no history of any prolonged drug intake. On examination, he was found to have periorbital puffiness and mild pedal edema.