HIV/AIDS may be a significant explanation for death and disability, especially in low- and middle-income countries. Prevalence rates in mentally ill inpatients and outpatients have been reported to be between 5% and 23%, compared with a range of 0.3% to 0.4% in the general population in the United States of America over comparable time periods. Some studies have reported behavioral risk factors for transmission of HIV in between 30% and 60% of people with severe mental illnesses. These risks include high rates of sexual contact with multiple partners, injecting drug use, sexual contact with injecting drug users, sexual abuse unprotected sex between men and low use of condoms. About 10% of HIV cases worldwide are attributable to injecting drug use .Injecting drug users principally acquire HIV through sharing injection equipment, whereas non-injecting use of drugs, such as cocaine or amphetamine-type stimulants, is associated with transmission of HIV through high-risk sexual behaviors. Drug dependence is associated with particularly high-risk patterns of drug use and related risks of HIV transmission.