A study evaluating psychosocial aspects of children with GCMN revealed that emotional or behavioral problems occur in up to 26% of cases, and social problems affect about 30% of patients. These issues arise as a result of an impaired self-image caused by the presence of the nevus, the anxiety over the risk of complications such as melanoma, the discomfort caused by multiple invasive treatments and even by the unsightly appearance of surgical scars. Cutaneous symptoms eventually caused by the melanocytic lesion, contribute to the exacerbation of emotional disorders. Parents and other family members also often present with psychological symptoms associated with the difficulty in accepting the congenital problem and dealing with its implications.One of the serious complications of GCMN is neurocutaneous melanosis (NCM), a rare syndrome with just over 100 symptomatic cases described in the literature. It is characterized by the presence of benign or malignant melanocytic proliferations in the CNS associated with the occurrence of congenital melanocytic lesions. Melanocytic cells are found in large number (in nodules or diffusely distributed) in the leptomeninges of the brain and / or spinal cord. Although the location of these cells is similar to that occurring under physiological conditions (in up to 85% of individuals), the extent of infiltration differentiates these patients from the normal population.