High-impact journals are those considered to be highly influential in their respective fields. The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years. Cytogenetics can be defined as that deals with the study of structure and function of the cell, mainly focussing on the structure and composition of the cell. Cytogenetic tests are usuallly carried out during the time of pregnancy to determine any structural or chromosomal abnormalities in the fetus. As the changes occur in the chromosomes, thus disrupting the genes and finally leading to the production of fatal or abnormal proteins, thereby resulting in mild to severe or lethal birth defects.