The new herbicides were revolutionary in that their high toxicity allowed for effective weed control at dosage rates as low as one to two kilograms per hectare (one or two pounds per acre). This contrasted with carbon bisulfide, borax, and arsenic trioxide, which were required at rates of up to 2,242 kilograms per hectare (one ton per acre), and with sodium chlorate, required at rates of around 112 kilograms per hectare (100 pounds per acre). However, some of those early herbicides, including 2,4,5-T, were later deemed unsafe for humans and the environment and were discontinued in many countries. Effective herbicides have continued to be developed, and some, such as glyphosate, are widely used around the world.