Bioinformatics is the combination of health information, data and knowledge. It uses computational techniques and tools to analyze the enormous biological data bases. The diseases such as metabolic disorders, urea cycle disorders, inborn errors and path-aligner can be identified at the early stage using various bioinformatics computational tools. These tools are used to process genetics and proteomics data and compare with health care data. Health care data consists of physiological data from various muscles or organs co acquiesced by using various electronic components, cost reports, bill claims and surveys related to patient satisfaction. Health care analysts are helpful to provide best health care at the lower price which is good for family economic system. This paper briefly explains the history applications of bioinformatics. The brief information about various kinds of computational tools and databases with respect to the application are mentioned. The current research trends in the bioinformatics are concluded.