The field of pharmacogenetics is changing rapidly today. The “common disease-common variants hypothesis†based GWAS have not fulfilled the expectation in the scientific community after a great deal of effort. In contrast, since NGS can enable us to identify all the causative variants (including both common and rear genetic variants) this approach is driving the next wave in pharmacogenetics. Journal of Pharmacogenomics & Pharmacoproteomics is making significant contributions to our understanding of pharmacogenetics and will redefine the field of personalized medicine. It is likely that key advancements will be seen soon. Huixiao Hong, Next-Generation Sequencing and Its Impact on Pharmacogenetics.