Journal of Bioinformatics and Systems Biology covers all the major topics such as Analysis and modelling of complex systems, Comparative genomics, Data visualization, Imaging and image analysis, Knowledge-based analysis, Machine learning and artificial intelligence in bioinformatics, Networks analysis, Novel computational methods for the analysis of biological systems, Proteomics, Sequence analysis, Structural analysis, Transcriptome analysis, DNA sequencing, Sequence assembly, Genome annotation, Computational evolutionary biology, Comparative genomics, Pan genomics, Genetics of disease, Analysis of mutations in cancer, Gene and protein expression, Analysis of gene expression, Analysis of protein expression, Analysis of regulation, Analysis of cellular organization, Microscopy and image analysis, Protein localization. Free journals are those online publications which does not holds any publication charge. It aims to provide financial assistance and support to the young bussing researchers or academicians from middle or lower economies thus accelerating research in their areas and thus stimulating the scientific and technological growth of the country. It prevents the authors from paying exorbitant prices under the various open access journals and thus provides financial stability. The strategy is implemented with an aim to serve the scientific cause and not with commercial aspects. Journal of Applied Bioinformatics & Computational Biology finds top positions among free bioinformatics journal by following hybrid mode of publications.