Proteases establish one of the essential focuses in sedate revelation. In the current audit, we center around extracellular proteases (ECPs) due to their differential articulation in numerous pathophysiological forms, including malignant growth, cardiovascular conditions, and fiery, aspiratory, and periodontal illnesses. Numerous new ECP inhibitors are presently under clinical examination and a noteworthy increment in new treatments dependent on protease restraint can be normal in the coming years. Notwithstanding legitimately hindering the movement of a focused on protease, one can exploit differential articulation in illness states to specifically convey remedial or imaging operators. Ongoing examinations in focused medication advancement for the metalloproteases , serine proteases (elastase, coagulation factors, tissue/urokinase plasminogen activator framework, kallikreins, tryptase, dipeptidyl peptidase IV), cysteine proteases (cathepsin B), and renin framework are talked about herein.A number of likely focuses for the improvement of new therapeutics to treat human ailment are currently promptly given by genomics and proteomics 1, 2. Proteins are the principle focuses for medication or antibody disclosure and among them proteases establish one of the fundamental classes 3, 4. Out of the around 500 medication focuses on that are as of now known, around 200 are catalysts, and over 60% of the all out compound market is comprised of proteases. Proteases turned out to be monetarily significant medication focuses upon the acknowledgment that, other than their essential capacity in the hydrolysis of peptide bonds, they were critical flagging particles associated with various indispensable procedures. As indicated by bioinformatics examination of the human genome, 566 proteases had been distinguished up until now. Of these, 273 have been found in extracellular compartments or in the lumen of secretory compartments, 277 in intracellular compartments, and 16 in the cell film at the surface 5. The focal point of this survey will be on extracellular proteases (ECP), a mind boggling and heterogenous group of catalysts