Esophageal cancer is a disease in which malignant (cancer) cells form in the tissues of the esophagus. Smoking, heavy alcohol use, and Barrett esophagus can increase the risk of esophageal cancer. Signs and symptoms of esophageal cancer are weight loss and painful or difficult swallowing. Symptoms and Signs are Difficulty and pain with swallowing, particularly when eating meat, bread, or raw vegetables, Pressure or burning in the chest, Indigestion or heartburn, Frequent choking on food, Unexplained weight loss, Coughing or hoarseness, Pain behind the breastbone or in the throat, Difficulty swallowing (dysphagia) Weight loss without trying. Chest pain, pressure or burning.