Epidemiology is the appeal for high particularity categorize of disease agents: to confirm trace back of disease to origin, to monitor the spread of disease causing strains, to study population dynamics of the disease strain, to discern endemic/enzootic from epidemic/epizootic infections, to detect the presence of multiple strain in the population and/or individual, to identify modes of transmission of the disease agent from host to host, and to address alternative epidemiological questions or issues. Molecular subtyping has been generally found to be better than most traditional phenotypic subtyping methods because it is usually more discriminating and less influenced by the organisms’ responses to environmental cues.