Technology has been a major driver of advances in drug discovery. Automation, nanofluidics, imaging, software and assay technologies have played a major role in getting better data, faster. The drug discovery process covers a broad range of disciplines from genomics and target discovery to pre-clinical testing. Within this space there are a variety of hardware, software and biological technologies. As much as homogenous fluorescent methods (and similar assay technology innovations) have advanced drug discovery, they do not have universal applications and there is always the inherent danger that labels or conjugated molecules of any type will change the interactions being measured. For these reasons, along with the expense and labelling time, there has been considerable activity in the search for reproducible and inexpensive label-free technologies.