Down’s syndrome (DS), the most typical autosomal ailment, besides having mental retardation and development put off, have standard phenotype that make this syndrome one of a kind from other syndromes. Goals: To evaluate our statistics on DS with different studies completed in India and overseas. Cloth & techniques: Chromosome take a look at become done in 118 instances of clinically diagnosed Down’s syndrome referred to Human Genetic research cum Counselling centre, Jammu. The study turned into accomplished shape the peripheral blood lymphocyte tradition. Results: Charomosomal abnormalities might be detected in fifty nine instances (50.0%). In these kind of 59 instances trisomy 21 changed into detected, but fifty one cases (43.22%) had standard or loose Trisomy (47, XY+21 or 47,XX +21), one case (0.84%) become found to have double Trisomy (48, XXX+ 21) and 7 instances (5.9%) had Mosaicism (47,XY+21/46, XY and 47, XX+ 21/46, XX). Parameters like Parental age, intercourse ratio (Male/girl), Consanguinity, birth Order, faith and local vicinity (rural/urban) had been also studied to discover the association, if any, of those elements with the Down’s Syndrome beginning. end: the prevailing study although includes a small wide variety referred cases, it honestly demonstrates the importance of chromosomal analysis for referred DS cases. Even though DS can be clinically recognized, cytogenetic examination no longer most effective helps to verify the chromosomal abnormality however is also fundamental for Genetic Counselling and prevention of further offspring with DS in affected families. The locating of this look at will assist in managing DS children and counselling the affected households.