Down syndrome or Down's syndrome, otherwise called trisomy 21, is a hereditary issue brought about by the nearness of all or part of a third duplicate of chromosome 21. It is typically connected with physical development delays, gentle to direct savvy handicap, and trademark facial highlights. The normal IQ of a youthful grown-up with Down syndrome is 50, proportional to the psychological capacity of a 8-or 9-year-old kid, however this can shift generally. The guardians of the influenced individual are typically hereditarily ordinary. The likelihood increments from under 0.1% in 20-year-old moms to 3% in those old enough 45. The additional chromosome is accepted to happen by some coincidence, with no known conduct movement or natural factor that changes the likelihood. Down syndrome can be recognized during pregnancy by pre-birth screening followed by demonstrative testing or after birth by direct perception and hereditary testing. Since the presentation of screening, pregnancies with the conclusion are regularly ended. Customary screening for medical issues normal in Down syndrome is suggested all through the individual's life. downs syndrome high impact factor journals has been successfully publishing quality research articles from many years and looking forward to frame up an eminent, outstanding issue with best quality research articles in this year. We request you to kindly submit and publish your paper in the best journal and get global acknowledgement.