Diabetic foot ulcer may be a major complication of DM, and doubtless the main component of the diabetic foot. Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is the stepwise repair of the lost extracellular matrix (ECM) that forms the most important component of the dermal skin layer. But in some cases, certain disorders or physiological insult disturbs the wound healing process. Diabetes mellitus is one such disorder that impedes the traditional steps of the wound healing process. Many studies show a protracted inflammatory introduce diabetic wounds, which causes a delay within the formation of mature granulation and a parallel reduction in wound lastingness. Treatment of diabetic foot ulcers should include: blood glucose control, removal of dead tissue from the wound, wound dressings, and removing pressure from the wound through techniques like total contact casting.