Diabetes is that the seventh-leading explanation for death within the us . In 2015, 30.3 million Americans had diabetes. Of these, 7.2 million had not received a diagnosis.1 About 1.5 million new cases are diagnosed annually within the us . Diabetes is emerging together of the foremost prevalent human ailments next to cardiovascular diseases and is that the sixth leading explanation for death worldwide (WHO). Etiologically, DM (DM) may be a heterogeneous disorder characterized by abnormal glucose homeostasis and insulin resistance. the basis explanation for diabetes involves complex mechanisms. Diabetes is of two types – Type 1 and sort 2. Type 1 DM is juvenile diabetes/insulin-dependent DM (IDDM) characterized by pancreas failure to supply insulin on account of cell destruction. it's prevalent in young age like in children, adolescents and young adults. On the opposite hand, type 2 DM (T2DM) is type II diabetes and is named as non-IDDM resulting thanks to inability of cells/tissues to reply properly to the action of insulin. aside from these, other factors like genetic and metabolic abnormalities also are accountable.[1] variety of studies has related diabetes to cancer risk. Furthermore, growing evidences suggested an abnormal glucose homeostasis as an independent risk factor for the event of specific neoplasms and affecting the prognosis of cancer.[2,3] Several epidemiological studies have found that diabetic patients have an increased risk of various sorts of cancers, for instance , liver, biliary tract, pancreas, stomach, colorectum, kidney, bladder, breast, and endometrium.[4,5,6,7,8,9,10,11,12] Contrarily, a reduced incidence of prostatic adenocarcinoma has been reported in individuals with diabetes.[13] In recent years, spectacular advances happened in interpreting the etiology of diabetes and cancer. Novel cancer biomarkers (CBs) are studied to guage the danger of cancer in prediabetic and nondiabetic individuals. Therefore, challenge within the cancer research would be the identification of novel CBs that would be used as prognostic and diagnostic tools. CBs are present in tumor tissues or fluids and include a good sort of molecules like DNA, mRNA, transcription factors, cell surface receptors, secreted proteins, and little metabolites.