Diabetes insipidus (die-uh-BEE-teze in-SIP-uh-dus) is an uncommon disorder that causes an imbalance of fluids in the body. This imbalance makes you very thirsty even if you've had something to drink. It also leads you to produce large amounts of urine. A disorder of salt and water metabolism marked by intense thirst and heavy urination.Diabetes insipidus occurs when the body can't regulate how it handles fluids. The condition is caused by a hormonal abnormality and isn't related to diabetes.In addition to extreme thirst and heavy urination, other symptoms may include getting up at night to urinate, or bed-wetting.Depending on the form of the disorder, treatments might include hormone therapy, a low-salt diet and drinking more water.