The pathophysiology of dementia. Plum F. Dementia is a symptom of a spread of particular structural brain sicknesses in addition to several gadget degenerations. Alzheimer's disease currently is the most typical purpose inside the developed international, inflicting a cortical-subcortical degeneration of ascending cholinergic neurons and massive pyramidal cells in the cerebral cortex. Clinically, the disorder reflects predominantly deterioration of feature within the association cortex. Clinicians from numerous disciplines and medical specialties are properly poised to relieve suffering, aggressively deal with contributing conditions, employ medicines to improve cognitive, neuropsychiatric, and motor signs, sell proof-based totally mind-healthy behaviors, and improve universal first-rate of life for sufferers and families.