To determine the effects of NADPH on KA-induced excitotoxicity, neuronal survival, neurologically behavioral score and oxidative stress were evaluated. To explore the mechanisms of neuroprotective effects of NADPH, the autophagy-lysosome pathway related proteins were detected.There are a few of excitatory amino acids in the central nervous system (CNS) of mammal, the most common of which are glutamate and aspartate. Glutamate is the primary excitatory neurotransmitter in mammalian brains and the research regarding glutamate receptors (GluR) has attracted extensive interest for their pivotal roles in neural development, differentiation and synaptic plasticity.