The COVID-19 Impact in Mexico is part of the ongoing worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus was confirmed to have reached Mexico in February 2020. However, the National Council of Science and Technology (CONACYT) reported two cases of COVID-19 in mid-January 2020 in the states of Nayarit and Tabasco, one case per state. As of June 24, there had been 196,847 confirmed cases of COVID-19 in Mexico and 24,324 reported deaths, although the Secretariat of Health estimated in early May 2020 that there were more than 104,562 cases in Mexico, because they were considering the total number of cases confirmed as a statistical sample. On January 22, 2020, the Secretariat of Health issued a statement saying that the novel coronavirus COVID-19 did not present a danger to Mexico. 441 cases had been confirmed in China, Thailand, South Korea, and the United States, and a travel advisory was issued on January 9. On January 30, 2020, before the declaration of a pandemic by the World Health Organization the Government of Mexico designed a Preparation and Response Plan that was made by the National Committee for Health Safety, a working group led by Secretariat of Health composed by different health entities aiming to act upon the imminent arrival of the pandemic. This group carried out a series of alert measures, rehabilitation and updating of epidemiological regulations based on the International Health Regulations, being the first Latam country that deployed a mathematical modelling of infectious disease.