Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system that is frequently associated with cognitive deficits, depression and fatigue. These factors lead to a decline in the quality of life, social withdrawal and unemployment. Patients with MS are less exposed to different types of activities: professional and social, and are more likely to suffer from psychiatric disorders, in particular depression. Cognitive impairment in MS patients is heterogeneous. In some of them, cognitive impairment does not occur in any form, in others, such symptoms can be the cause of a severe and progressive form of the disease from the start, even before a physical disability. About half of all people with MS (40 to 60%) will develop cognitive problems. Most studies indicate that cognitive impairment is more common in patients with primary or secondary MS with progressive release and slightly more in the form of secondary disease than primary progressive.