Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. It is part of the renin-angiotensin system, which regulates blood pressure. Angiotensin also stimulates the release of aldosterone from the adrenal cortex to the sodium retention of the kidneys. Oligopeptide, angiotensin is a hormone and a dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. Angiotensin was isolated in the late 1930s (first named "angiotonin" or "hypertensin") and then characterized and synthesized by groups. Angiotensinogen is an α-2-globulin synthesized in the liver It is part of the serpin protein family, leading to another name: Serpin A8, although it is not known to inhibit other enzymes. . In addition, a crystal structure
Angiotensin I is converted to angiotensin II (AII) by two C-terminal residues of the angiotensin converting enzyme (ACE), mainly by ACE in the lung (but also present in endothelial cells, renal epithelial cells and brain). . Angiotensin II acts on the CNS to increase vasopressin production, and also acts on the venous and arterial smooth muscle cause vasoconstriction. Angiotensin II also increases the secretion of aldosterone; It therefore acts as an endocrine, autocrine / paracrine and intracrine hormone