Gene Technology is among the best peer-reviewed journals which are characterized by impaired with understanding the expression of genes, taking advantage of natural genetic variation, modifying genes and transferring genes to new hosts. Articles published in this peer-reviewed journal are properly reviewed by at least two reviewers of the associated fields. It mainly provides expression of genes, taking advantage of natural genetic variation, modifying genes and transferring genes to new hosts, Environmental Biotechnology, Cell biology, Genetic Engineering and Molecular Biology, Tissue Engineering, Biosensor, Cancer Biology, Bioinformatics and Computational biology. The eukaryotic chromosome is linear, with a centromere and telomere. The chromosome replicates from the origin of replication during the S-phase of the cell cycle. The centromere proteins, CENP-A,-B, and -C, located in the centromere sequence, assist with assembly of the kinetochore complex during the M phase. Then, the spindle fiber is attached to the kinetochore, and the chromosome is distributed to both poles. In this way, replicating chromosomes are distributed to daughter cells, and the genomic information of a mother cell is stably transmitted to daughter cells. Physiologically, the same mechanisms are used for the replication and distribution of HAC vectors. "Mitsuo Oshimura, Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells" PrimeOA Publications is one of the top open access publishers with 700+ peer-reviewed journals along with eminent scientists in its Editorial Board and expert reviewers to carry rigorous peer-review process. The peer review process is highly appreciated by researchers globally. Editorial Board Members and Reviewers actively participate in the review process within 21 days and ensure the quality of the manuscripts. In addition to open-access publishing, PrimeOA Publications also provides E-books, Scholar Central and more than 3000+ International Scientific Conferences under its umbrella.