Malaria continues to dominate the scene involving the infectious diseases even though the î‚¿gures suggest that the
incidence of malaria is decreasing. Transmitted by the bite of the anopheles mosquito, malaria has undergone varying
epidemiological and clinical changes with Plasmodium vivax malaria becoming complicated along with the Falciparum
malaria with multi-organ involvement and can be fatal at times. Early and accurate diagnosis of malaria is imperative
for effective management. More recently, Rapid Diagnostic Tests (RDTs) have been introduced into routine use, and
molecular methods like polymerase chain reaction are useful in certain situation. Artemesinin based combination
therapy have become the drug of choice especially for complicated malaria with Synriam being the latest addition
which is a î‚¿xed dose formulation containing the short acting arterolane and long acting piperaquine.