Case reports are based on mainly six topics like: an unexpected association between diseases or symptoms an unexpected event in the course of observing or treating a patient, findings that shed new light on the possible pathogenesis of a disease or an adverse effect, unique or rare features of a disease, unique therapeutic approaches, a positional or quantitative variation of the anatomical structures. A case report is generally considered a type of anecdotal evidence. Case reports may also have a role to play in guiding the personalization of treatments in clinical practice.