Cancer has become of the dreadful diseases of all times. Despite discovery of drugs, and invention of other alternative to treat cancer, the mortality rate of cancer has been increasing. Innovative cancer treatment involves treatment of cancer by innovative methods, which would decrease the side effects and also increase efficiency in curing cancer. Some of the innovative cancer treatments are gene therapy, immunotherapy, hormone replacement therapy, targeted drug delivery systems; Cancer vaccines are one of the innovative cancer therapies which would treat cancer in an effective way. Surgeons often use small, thin knives, called scalpels, and other sharp tools to cut your body during surgery. Surgery often requires cuts through skin, muscles, and sometimes bone. After surgery, these cuts can be painful and take some time to recover from. The innovative cancer therapies are interesting besides being challenging too. Some of the innovative cancer drug therapies are gene therapy, laser therapy, application of nanotechnology (nanoparticles therapeutics), RNA interference therapy, photosensitizer and hyperthermia.