The individuals who have CKD-MBD may have another bone issue, osteoporosis, which is the most widely recognized metabolic bone malady bringing about delicacy cracks. With expanding life expectancies, the populace with osteoporosis is developing [2, 3], and, in everybody, about 85% of ladies with osteoporosis have some decay of renal capacity [4]; both are most likely inferable from more prominent age [5]. Notwithstanding, osteoporosis additionally includes low bone mass, a disarranged microarchitecture, and skeletal delicacy, and consequently this condition adds to the danger of break, particularly in the spine, hip, wrist, humerus, and pelvis [6]. Since delicacy cracks, diminished glomerular filtration rate (GFR), and low bone mineral thickness (BMD) are normal in the more established populace, it very well may be a test to separate the reason for a delicacy break or potentially low BMD in old CKD (especially with evaluated eGFR <30 mL/minute) patients as either osteoporosis or another bone and mineral issue identified with CKD (e.g., hyperparathyroidism, adynamic bone sickness, and osteomalacia) [7] (Table 1). Patients with an age-related decrease in eGFR to 30 mL/min profit by oral or intravenous bisphosphonates for osteoporosis [8, 9], however the utilization of bisphosphonates in CKD requires some alert. Essential administration of CKD with low mineral thickness is fundamental for understanding the pathogenesis of these two bone issue and structuring a normal way to deal with treatment and avoidance of intricacies.