A blood clot, or a thrombus, increases the risk of complications and death among those who have COVID-19. This disease causes blood clots in 20–30% of critically ill patients. This article will look at the link between the novel coronavirus and blood clots and discuss some potential treatments and methods of prevention. Blood clotting is one of the body’s natural responses to injury. It occurs when a volume of blood changes to a semi-solid state in order to prevent excessive blood loss. Several chemical reactions in the body facilitate this change. Clots that form inside a deep vein, however, can be extremely dangerous. These clots may not dissolve on their own, and they can stop blood flow. This can be fatal. In some situations, a clot can break off and travel to another part of the body. This thrombus becomes known as an embolus. If the embolus reaches the brain, heart, or lungs, it can result in a life threatening condition, such as a heart attack or stroke. One theory is that the clotting occurs when the novel coronavirus attacks the endothelial cells that line the blood vessels. The virus does this by binding to the ACE2 receptors, which are present in the endothelial cell membrane. Once the virus binds to these receptors, the blood vessels start releasing proteins that trigger blood clotting. Another theory is that COVID-19 causes the body’s immune system to trigger a hyperactive inflammatory response. This inflammation may then trigger clotting.