Biostatistics is the branch of statistics responsible for the proper interpretation of scientific data generated in the biology, public health and other health sciences (i.e., the biomedical sciences). In these sciences, subjects (patients, mice, cells, etc.) exhibit considerable variation in their response to stimuli. This variation may be due to different treatments or it may be due to chance, measurement error, or other characteristics of the individual subjects. Open access to the scientific literature means the removal of barriers (including price barriers) from accessing scholarly work. There are two parallel “roads” towards open access: Open Access articles and self-archiving. Open Access articles are immediately, freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is self-archiving (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals.