The Association of Public Health Laboratories, Centers for Disease Control and Prevention, and (Your Public Health Lab) are enhancing support to clinical and local health department laboratories to reduce risk in the areas of laboratory biosafety and biosecurity. As such, new programmatic support has been developed and conversations around biorisk management will be incorporated into ongoing outreach programs. This document provides an overview of a comprehensive, systematic approach to laboratory biorisk management. It includes a list of essential elements laboratories can use to assess their operations and better integrate and enhance programs for biosafety and biosecurity.