With either type of needle biopsy, the needle is passed several times through the tissue being examined. The doctor uses the needle to remove the tissue sample. Needle biopsies are often done using a CT scan, MRI, mammogram, or ultrasound. These imaging tools help guide the doctor to the right area. An open biopsy is a surgery that uses local or general anesthesia. This means you are relaxed (sedated) or asleep and pain-free during the procedure. It is done in a hospital operating room. The surgeon makes a cut into the affected area, and the tissue is removed. A laparoscopic biopsy uses much smaller surgical cuts than open biopsy. A camera-like instrument (laparoscope) and tools can be inserted. The laparoscope helps guide the surgeon to the right place to take the sample. A skin lesion biopsy is done when a small amount of skin is removed so it can be examined. The skin is tested to look for skin conditions or diseases.