The disturbance of the blood-cerebrum hindrance (BBB) plays a basic occasion in the pathogenesis of ischemia stroke. TGR5 is perceived as a potential objective for the treatment of neurologic issues. This examination researched the jobs of TGR5 initiation in lessening BBB harm and basic instruments after center cerebral course impediment (MCAO). Sprague-Dawley rodents were exposed to a model of MCAO and TGR5 agonist, INT777, was regulated intranasally. Little meddling RNA (siRNA) for TGR5 and BRCA1 were regulated through intracerebroventricular infusion 48 h before MCAO. Infarct volumes, mind water content, BBB penetrability, neurological scores, Western blotch, immunofluorescence recoloring, and co-immunoprecipitation were assessed.