Biologically inert, or Bioinert materials are ones which do not initiate a response or interact when introduced to biological tissue. In other words, introducing the material to the body will not cause a reaction with the host. The reason that this type of material has been conceived is because materials initiating a response may detrimentally affect the host. Bioinert materials are non-specifically downregulate in biological responses. These materials were developed originally as non-thrombogenic surfaces for vascular surgery, and are often referred to as hemocompatible; but have a number of possible applications in the eye and other biological fluid contacting environments.