Biochips refer to the complete fundamental functional unit, capable of performing multi biochemical tasks simultaneously. Tissue chips on the other hand are similar miniaturized units that can replace a tissue or some part of it, enabling the organ to work normally. Both biochips & tissue chips have been elemental in tissue engineering technology and have proven to be of utmost importance in the same arena. DNA microarray also called as biochip in simple terms consists of a two dimensional grid system where upon sensors or solid flat substrates are incorporated. These solid substrates can be either positively charged just like silicon or glass or can also be consisting of integrated circuitry units that perform best in signal transduction studies. Biochip development will benefit increasingly from applications developed for other industries. For example, flame hydrolysis deposition (FHD) of glasses has many applications in the telecommunications industry, and is now also being applied toward the development of new biochips. A recent report describes how FHD was used to deposit silica with different refractive indices, resulting in microstructures that can be readily incorporated onto a chip and that integrate both optical and fluidic circuitry on the same device.