Folliculogenesis is a processofovarian follicles growth and development, which is the interaction of oocyte and granulosa cells with resulting in mature and fertilizable oocytes. There are two crucial growth factors that play a role in the interaction of oocyte and granulosa cells, namely Growth Differentiation Factor-9 (GDF-9) derived from oocyte and Kit-Ligand produced from granulosa cells. In abnormal folliculogenesis, the interaction of both growth factors could disturb the growth of follicles in the ovaries. The use of bone marrow mesenchymal stem cells, which have the ability to regenerate itself and differentiate into other tissue cells, has been tried for regeneration therapy of various diseases.