Journal of Liver is the best open access journal in Liver physiology. All published articles are permanently archived and available at PrimeOA Publications website in HTML, Digital, Audio and PDF formats. All the submitted papers undergo a stringent peer-review process that aims to improve and maintain the International standards both in terms of novelty and content. The liver is a vital organ located in the right upper area of your abdomen under the ribs. Liver failure is a life-threatening condition in which there is a severe deterioration of liver function. Liver failure is caused by liver damage, which makes it difficult or impossible for the liver to function normally in processes that are critical to life and your overall health including Blood clotting, clearing the blood of toxins, fighting infection, removing waste, metabolizing medications and other substances etc. The liver is composed of lobules, 0.8 to 2 mm in diameter. They comprise a central vein (which drains to the hepatic vein) surrounded by plates of hepatocytes sandwiching bile canaliculi and surrounded by the space of Disse (which drains to lymphatics). Between the plates are sinusoids filled with blood derived from the hepatic artery (350 ml/min) and portal vein (1.1 l/min). The liver receives a total of 29% of resting cardiac output. It is a low-resistance circulation, the portal vein being at 9 mmHg and hepatic vein at 0 mmHg