A major goal of research on drug and alcohol is to understand the main points associated with the transition state from drug use to drug dependence. These are international peer reviewed open access journals. The best open access drug dependence journals provide an evaluation on drug use and abuse, its effect on life and also treatment of various harmful effects of alcohol. Substance abuse is a global problem with geographical variations in patterns of abuse. One of the most words commonly used and misused substances is alcohol. Alcohol is a drug. It is classified as a depressant, implying that it slows down vital functions resulting in slurred speech, unsteady movement, disturbed perceptions and an inability to react quickly. Drug reduces a person’s ability to think rationally and distorts his or her judgment.On the other hand, alcohol consumption causes problems at the individual, social, health and financial level. Also, it makes the person feel happy only at a specific time. Moreover, it causes a lot of health problems.Then, excessive alcohol consumption negatively affects all organs of the body, the liver, the immune system, and heart. Besides, driving drunk can cause many problems for every one as well as traffic, accidents. However, some people consider that alcohol is good for the health and that drinking alcohol makes an individual relaxed and more sociable.