Ayurveda is a one of the oldest medical systems, science of life with a holistic approach to health and personalized medicine. which comprises thousands of medical concepts and hypothesis. Interestingly, Ayurveda has ability to treat many chronic diseases such as cancer, diabetes, arthritis, and asthma, which are untreatable in modern medicine. Unfortunately, due to lack of scientific validation in various concepts, this precious gift from our ancestors is trailing. Hence, evidence-based research is highly needed for global recognition and acceptance of Ayurveda, which needs further advancements in the research methodology. The present review highlights various fields of research including literary, fundamental, drug, pharmaceutical, and clinical research in Ayurveda.This attempt will certainly encourage young researchers to work on various areas of research for the development and promotion of Ayurveda. The review further focuses to improve the research methodology for Ayurveda with main emphasis on the fundamental research.