Mesenchymal stem cells (MSCs) are multipotent cells that secrete a variety of bioactive factors, which actively contribute to their environment. These cells are also capable of changing to suit their environment, being responsive to host tissue cues. These tissues can be diverse ranging from bone, cartilage, lungs, pancreas, the central nervous system, the gastrointestinal track, and the circulatory system . These properties could be helpful in scenarios of tissue damage, inflammation, and infection associated with these organs implicating the power of MSCs therapeutic potential: versatility and applicability. However, from a research standpoint, this property can be conflicting, as the impact of MSCs themselves is still controversial. The issue begins with the unknowns, as it has not been concluded whether the improvement in the damaged tissue or area of inflammation and infection is because of the MSCs or whether the improvement is caused by the tissues’ response to the MSCs or both . This review will give insight into the research and clinical trials that are being done to determine the efficiency of stem cells in a host of different environments, as well as new avenues for patient care.