Auto inflammatory diseases ask problems with the system, which usually fights off viruses, bacteria, and infection. The matter causes your immune cells to attack your body by mistake. This will cause swelling that produces fever, rash, joint swelling, or serious buildup of a blood protein in your organs.
Autoinflammatory diseases refer to problems with the immune system, which usually fights off viruses, bacteria, and infection. The problem causes your immune cells to attack your body by mistake. This can cause swelling that produces fever, rash, joint swelling, or serious buildup of a blood protein in your organs.
The pathogenetic mechanisms underlying auto inflammation, although still unclear and different from each other from a molecular point of view, are always responsible of an aberrant activation of innate immunity. The result is a systemic involvement of multiple organs and systems, even when the clinical manifestations are predominant in specific organs. The main clinical feature of both monogenic and multifactorial forms is therefore a marked systemic involvement, also in early stages. Several organs and systems are in fact affected by inflammation and severe clinical manifestations may often occur unpredictably in different tissues and at different times. Almost every organ might be involved, making clinical aspects extremely variable and complex.