Neurodevelopment disorders occur worldwide without geographic boundaries. Angelman syndrome, Fragile X syndrome (FXS), Prader-Willi syndrome, Tuberous Sclerosis Complex, Velo-cardiofacial syndrome and Williams syndrome, are caused by a known location(s) on a specific chromosome(s) are monogenic disorders. Conversely, Attention-deficit and hyperactivity disorder (ADHD), Autism spectrum disorders (ASD), Bipolar disorder, Joubert syndrome, Obsessive compulsive disorder, Schizophrenia and Tourette syndrome are likely caused by unknown common variants of many genes, on many chromosomes, each contributing a subtle effect [polygenic disorders]. Monogenic disorders follow the Mendelian inheritance (autosomal dominant, recessive, X-Linked) which is largely caused by single major genes, the genes involved in these Mendelian disorders could effectively be characterized by linkage analysis and other molecular techniques once the pattern of transmission was established as consistent with a particular genetic model. Conversely, polygenic disorders do not follow the simple Mendelian inheritance. They are complex (polygenic) due to imprinting, mitochondrial inheritance, genetic heterogeneity, variable clinical expression, age of onset, and incomplete penetrance. The predisposition of polygenic disorders is determined by a complex interaction of multiple genetic and environmental factors. Therefore, the exact patterns of transmission, the extent of genetic heterogeneity, the specific number of susceptibility loci, and the degree of the interaction between loci in these disorders are unknown. Journal of Metabolic Syndrome of PrimeOA Publications group is specialized in publishing its articles across a broad spectrum of polygenic disorder, Insulin resistance, Type 1 Diabetes, Type 2 Diabetes, Diabetes Therapy which enables the varied readers across the globe to access the content of their interest. Journal Article is sometimes called a Scientific Article, a Peer-Reviewed Article, or a Scholarly Research Article. Together, journal articles in a particular field are often referred to as The Literature. Journal articles are most often Primary Research Articles. However, they can also be Review Articles. These types of articles have different aims and requirements. Sometimes, an article describes a new tool or method