Primary adenocarcinoma of the urinary bladder accounts for approximately 0.5-2% of all bladder cancers. Hematuria, dysuria and suprapubic pain are general symptoms of patients. Radical surgery is regarded the most frequent treatment option, but it is not satisfactory in 5-year survival rates [1]. Patients often lose the chance to undergo the total cytectomy and then present the symptoms of hematuria, obstruction or compression. The symptoms lead to affecting the quality and life span of the patient. Neoadjiuvant chemotherapy can be a good option for patients with locally advanced primary adenocarcinomas of the bladder, helping downstage the cancer before surgery, eradicating potential micrometastases, and may avoid local and distant failure [2,3]. However, due to the rare morbidity of primary adenocarcinomas of bladder, the experience of chemotherapy is limited [4].The current study presents a case of 71-year-old man under the treatment of neoadjuvant chemotherapy.Ichthyosis vulgaris is a skin condition that causes dry, dead skin cells to collect in patches on the surface of your skin. It's otherwise called "fish scale infection" on the grounds that the dead skin aggregates in a comparative example to a fish's scales. Most of the cases are mild and bound to particular zones of the body. Notwithstanding, a few cases are serious and can spread extensive areas of the body, including the belly, back, arms, and legs. A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity.