Diabetes and liver cancer are among the leading causes of death worldwide. Diospyros species has been reported to have pharmacological applications arising from its extensive folkloric uses. The claims include anti-diabetic, antioxidant and antitumor properties. This study was carried out to investigate the anti-diabetic, antioxidant and hepatoprotective properties of D. pilosanthera, an endemic Philippine plant, and do a preformulation study. Diabetes was induced by a single intra-peritoneal dose of streptozocin (45 mg/kg body weight [BW]). The extract (200, 500 and 1000 mg/kg BW) and glibenclamide (control, 600 μg/kg BW) were administered orally to diabetic Sprague-Dawley rats. Moreover, hepatoprotective property of the extract was evaluated against Diethylnitrosoamine (DENA) induced liver toxicity in rats.