Biofilms are defined as a traditional pattern of microorganisms organized in microbial communities that are attached on an inert or living surface. Biofilms are embedded during a matrix containing polysaccharides, proteins, and extracellular microbial DNA Because provides a reservoir for microbial cells, its dispersion enhances the danger of chronic and protracted infections. it's going to also advertise the reinfection of colonized sites Likewise the matrix advise a protection against biocides and medicines and have environmental promoters that induce biofilm formation and contributes to drug resistance developmentStaphylococcus aureus is one among the foremost important biofilm-forming pathogens that cause complications starting from minor to life-threatening infections. Multidrug-resistant S. aureus which are isolated from clinical environments have a high probability of forming biofilms in indwelling medical devices (Kwon et al., 2008) and increase the probability of development into persistent, chronic, and recurrent infections (Francois et al., 2000). the power of S. aureus to make biofilm has drawn considerable interest from researchers over the past decade, particularly biofilms formed on catheters or implanted devices, bone, and prosthetic heart valves (Kiedrowski & Horswill, 2011; Fig. 1). Currently, biofilm infections are usually treated with combinations of antibiotics. In device-related biofilm infections, the device often has got to be removed and replaced surgically, which involves risk and complications (Hoiby et al., 2011). However, novel strategies in preventing and eradicating biofilm formation have recently been reported. during this review, we'll summarize the features of staphylococcal biofilm, the foremost recent advances within the elimination of biofilms and discuss the potential of those promising developments.