The history of infectious disease is fascinating! The history of mankind may be viewed and analyzed through the lens of infectious disease. Human history has been much affected by infectious diseases since the dawn of history.Disease is an abnormal condition of an organism that will exhibit specific symptoms and affects regular metabolism. It may be caused by external factors generally referred as foreign particles and will produce infectious diseases. These foreign particles will act as antigens, which will react with our immune system and finally leading to disease condition. Sometimes diseases will be produced by internal dysfunctions, which will lead to autoimmune diseases. Ancient Diseases are the diseases, which will provide information about characterization, diagnosis and treatment of various infectious diseases. These ancient diseases are acting as source of clinical and microscopic findings of a particular disease, by providing details like date and time of its emergence along with symptoms.