AIDS is the leading diseases which cause death among young adults. It is a disease caused by the human immunodeficiency virus (HIV) which slowly destroys the human immune system, thereby making infected people more susceptible and vulnerable to a variety of microbial infections. Mostly AIDS will be transmitted by unprotected sexual intercourse, blood transfusions, hypodermic needles, and mother to child transmission during pregnancy and delivery. Body fluids such as saliva and tears do not transfer the HIV from one person to another person. AIDS does not have any vaccines treatment to control the rate of transmission. Many clinical trials groups are doing research to explore the immune pathogenesis in the HIV infection, associated co infections, preventions, epidemiology, Microbicides, vaccines and novel drugs for treatment. Antiretroviral treatment is using to treat the HIV infection which may reduce the rate of risk and complications from the disease. But the treatment is more expensive with side effects. Review articles are the summary of current state of understanding on a particular research topic. Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.