AIDS is the leading diseases which cause death among young adults. It is a disease caused by the human immunodeficiency virus (HIV) which slowly destroys the human immune system, thereby making infected people more susceptible and vulnerable to a variety of microbial infections. Mostly AIDS will be transmitted by unprotected sexual intercourse, blood transfusions, hypodermic needles, and mother to child transmission during pregnancy and delivery. Body fluids such as saliva and tears do not transfer the HIV from one person to another person. AIDS does not have any vaccines treatment to control the rate of transmission. Many clinical trials groups are doing research to explore the immune pathogenesis in the HIV infection, associated co infections, preventions, epidemiology, Microbicides, vaccines and novel drugs for treatment