AIDS is the leading diseases which cause death among young adults. It is a disease caused by the human immunodeficiency virus (HIV) which slowly destroys the human immune system, thereby making infected people more susceptible and vulnerable to a variety of microbial infections. Mostly AIDS will be transmitted by unprotected sexual intercourse, blood transfusions, hypodermic needles, and mother to child transmission during pregnancy and delivery. Body fluids such as saliva and tears do not transfer the HIV from one person to another person. AIDS does not have any vaccines treatment to control the rate of transmission. Many clinical trials groups are doing research to explore the immune pathogenesis in the HIV infection, associated co infections, preventions, epidemiology, Microbicides, vaccines and novel drugs for treatment. Antiretroviral treatment is using to treat the HIV infection which may reduce the rate of risk and complications from the disease. High-impact journals are those considered to be highly influential in their respective fields. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.